Directory

 

 
 
General InformationPublicationsResearch Projects

  • A. D. Baik, J. Qiu, E. M. Hillman, Cheng Dong and X. E. Guo, 2013, "Simultaneous tracking of 3D actin and microtubule strains in individual MLO-Y4 osteocytes under oscillatory flow", Biochemical and Biophysical Research Communications, 431, (4), pp. 718-723
  • P. Khanna, C. Y. Chung, R. I. Neves, G. P. Robertson and Cheng Dong, 2013, "CD82/KAI expression prevents IL-8 mediated endothelial gap formation in late stage melanomas", Oncogenes
  • A. Ribeiro, P. Khanna, A. Sukumar, K. N. Dahl and Cheng Dong, 2013, "Nuclear stiffening inhibits migration of invasive melanoma cells", 2013 BMES Annual Conference
  • T. Ozdemir*, P. Zhang*, C. Fu* and Cheng Dong, 2012, "Fibrin serves as a divalent ligand that regulates neutrophil-mediated melanoma cells adhesion to endothelium under shear conditions", Am. J. Physiol Cell Physiol
  • Y. Fu*, R. Kunz, J. Wu and Cheng Dong, 2012, "Study of local hydrodynamic environment in cell-substrate adhesion using side-view mPIV technology", PLoS ONE, 7, (2), pp. e30721
  • T. Ozdemir*, P. Zhang*, C. Fu* and Cheng Dong, 2012, "Soluble fibrin determines the preferential adhesion of melanoma cells to polymorphoneutrophils (PMN) over endothelium in shear flow", The Journal of the International Society of Biorheology, 181
  • P. Khanna, T. Yunkunis, H. Muddana, A. August and Cheng Dong, 2010, "p38 MAP kinase in melanoma cell-induced endothelial VE-Cadherin regulation and junction disassembly", Am. J. Physiol. Cell - Physiol, 298, pp. C1140-1150
  • Y. Ma, J. Wang, S. Liang, Cheng Dong and Q. Du, 2010, "Application of population dynamics to study heterotypic cell aggregations in the near-wall region of a shear flow", Cellular and Molecular Bioengineering, 3, (1), pp. 3-19
  • A. D. Baik, X. L. Lu, J. Qiu, B. Huo, E. M. C. Hillmand, Cheng Dong and X. E. Guo, 2010, "Quasi-3D cytoskeletal dynamics of osteocytes under fluid flow", Biophys. Journal, 99, pp. 2812-2820
  • S. J. Huh, S. Liang, Cheng Dong and G. P. Robertson, 2010, "Transiently entrapped circulating tumor cells interact with neutrophils to facilitate lung metastasis development", Cancer Res., 70, pp. 6071-6082
  • P. Zhang and Cheng Dong, 2010, "Fibrin-mediated circulating tumor cell capture and adhesion to neutrophils", The 6th World Congress of Biomechanics
  • P. Khanna, A. August and Cheng Dong, 2010, "p38 MAP kinase is necessary for melanoma-mediatedregulation of VE-cadherin disassembly"
  • Cheng Dong, 2010, Adhesion and signaling of tumor cells to leukocytes and endothelium in cancer metastasis, Springer-Verlag, Berlin Heidelberg, pp. 42
  • P. Zhang, T. Ozdemir, C.-Y. Chung, G. P. Robertson and Cheng Dong, 2010, "Sequential binding of alpha v beta 3 and ICAM-1 determines fibrin-mediated melanoma capture and stable adhesion to CD11b/CD18 on neutrophil", J. Immunology
  • S. Leng, M. H. Hoskins and Cheng Dong, 2009, "Tumor cell extravasation mediated by leukocyte adhesion is shear rate-dependent on IL-8 signaling", Molecular and Cellular Biomechanics, 7, (2), pp. 77-91
  • Cheng Dong and G. P. Robertson, 2009, "Immunoediting of leukocyte functions within the tumor microenvironment and cancer metastasis development", Biorheology, 46, pp. 265-279
  • H.-H. Peng and Cheng Dong, 2009, "Systemic analysis of tumor cell-induced endothelial calcium signaling and junction disassembly", J. Cellular and Molecular Bioengineering, 2, (3), pp. 375-385
  • X. Mao, S. Lin, Cheng Dong and T. J. Huang, 2009, "Single-layer planar on-chip flow cytometer using microfluidic drifting based three-dimensional (3D) hydrodynamic focusing", Lab on a Chip, 9, pp. 1583-1589
  • D. Discher, Cheng Dong, J. J. Fredberg, F. Guilak, D. Ingber, P. Janmey, R. D. Kamm, G. W. Schmid-Schönbein and S. Weinbaum, 2009, "Biomechanics: Cell research and applications for the next decade", Ann. Biomed. Eng., 5, pp. 847-859
  • A. D. Baik, X. Lu, B. Huo, X. Liu, Cheng Dong and X. E. Guo, 2009, "A Semi-3D real-time imaging technique for measuring bone cell deformation under fluid flow", The ASME 2009 Summer Bioengineering Conference (SBC2009)
  • P. Khanna, A. August and Cheng Dong, 2009, "Tumor microenvironment and signaling affect endothelial VE-cadherin junction disassembly"
  • P. Zhang, T. Ozdemir and Cheng Dong, 2009, "Role of alphavbeta3 and ICAM-1 in plasma protein-mediated tumor cell and neutrophil heterotypic aggregation"
  • C. Kwang and Cheng Dong, 2009, "Chemokines from melanoma upregulate MMP2 within the tumor and endothelial microenvironment"
  • P. Butler, Cheng Dong, A. Snyder, A. Jones and E. Sheets, 2008, "Bioengineering and Bioinformatics Summer Institutes: meeting modern challenges in undergraduate summer research", Cell Biology Education Life Science Education, 7, (1), pp. 45-53
  • S. Liang, M. J. Slattery, D. Wagner and Cheng Dong, 2008, "Hydrodynamic shear rate regulates melanoma-leukocyte aggregations, melanoma adhesion to the endothelium and subsequent extravasation", Annals of Biomedical Engineering, 36, pp. 661-671
  • S. Liang, C. Fu, D. Wagner, H. Guo, D. Zhan, Cheng Dong and M. Long, 2008, "2D kinetics of beta2 integrin-ICAM-1 bindings between neutrophils and melanoma cells", Am. J. of Physiology, 294, pp. C743 - C753
  • S. Liang, S. J. Huh, G. P. Robertson and Cheng Dong, 2008, "B-Raf in Melanoma interrupts immunoediting of leukocyte functions and melanoma extravasation", pp. pp. 371:1079.23
  • M. H. Hoskins, R. F. Kunz, J. Bistline and Cheng Dong, 2008, "Coupled flow-structure-biochemistry simulations of dynamic systems of blood cells using an adaptive surface tracking method", J. Fluids and Structures, 25, pp. 936-953
  • S. Liang, M. H. Hoskins, P. Khanna, R. F. Kunz and Cheng Dong, 2008, "The tumor-leukocyte microenvironment in a shear flow and how it affects melanoma-neutrophil adhesion to the endothelium", Cellular and Molecular Bioengineering, 1, pp. 189-200
  • S. Liang and Cheng Dong, 2008, "Integrin VLA-4 enhances sialyl-negative melanoma adhesion to and extravasation through the endothelium under low flow conditions", Am. J. Physiol. Cell Physiol., 295, (3), pp. C701-C707
  • Cheng Dong, 2008, "Inhibiting IL-8 from melanoma cells interrupts tumor immunoediting and adhesion-mediated metastasis", pp. p. 54
  • M. Hoskins, R. F. Kunz and Cheng Dong, 2008, "Computational modeling of PMN-facilitatedmelanoma adhesion to the endothelium", 45, pp. p. 33
  • Cheng Dong, S. Liang, S. J. Huh, H. H. Peng and G. P. Robertson, 2008, "Immunoediting of leukocyte functions within the tumor microenvironment and cancer metastasis development", 45, pp. p. 39
  • S. Tada, Cheng Dong and J. M. Tarbell, 2007, "Effect of the stress phase angle on the strain energy density of the endothelial plasma membrane", Biophys. J.
  • Cheng Dong, S. Liang, A. Sharma, H.-H. Peng and G. P. Robertson, 2007, "Mechanisms linking inflammation and cancer", Proceedings of the 3rd Sin-American Workshop on Biomedical Engineering and China-Overseas Joint Workshop on Biomechanics, 22, (S), pp. 67-69
  • M. Hoskins, S. Liang, S. Gupta, R. Kunz and Cheng Dong, 2007, "A computational investigation into interactions between cancer cells and leukocytes in shear flow", pp. p. 85
  • M. Hoskins, S. Liang, R. Knuz and Cheng Dong, 2007, "Cellular mechanics and biology of tumor cell-leukocyte interactions in the near wall region under shear flow conditions", pp. p. 42
  • Cheng Dong, S. Liang, A. Sharma and G. Robertson, 2007, "Inflammation and cancer: Neutrophil-mediated melanoma extravasation is modulated by endogenous IL-8", pp. p. 52
  • W. J. Zhang, B. H. Li, X. Z. Yang, P. D. Li, Q. Yuan, X. H. Liu, S. B. Xu, Y. Zhang, J. Yuan, G. S. Gerhard, K. K. Masker, Cheng Dong, W. Koltun and M. J. Chorney, 2007, "IL-4-induced Stat6 activities affect apoptosis and gene expression in breast cancer cells", Cytokine, 42, pp. 39-47
  • H.-H. Peng, S. Liang, A. J. Henderson and Cheng Dong, 2007, "Regulation of interleukin-8 expression in melanoma-stimulted neutrophil inflammatory response", Experimental Cell Research, 313, pp. 551-559
  • S. Liang, A. Sharma, H. H. Peng, G. Robertson and Cheng Dong, 2007, "Targeting mutant (V600E) B-raf in melanoma disrupts immunoediting of leukocyte functions and melanoma extravasation", Cancer Research, 67, pp. 5814-5820
  • A. Sharma, M. A. Tran, S. Liang, A. K. Sharma, S. Amin, C. D. Smith, Cheng Dong and G. P. Robertson, 2006, "Targeting Mek in the nutant (V600E) B-raf signaling cascade effectively inhibits melanoma lung metastases", Cancer Research, 66, (16), pp. 8200-8209
  • M. H. Hoskins and Cheng Dong, 2006, "Kinetics analysis of binding between melanoma cells and neutrophils", Molecular and Cellular Biomechanics, 3, (2), pp. 79-87
  • J. Leyton-Mange, Y. Sung, M. Henty, R. F. Kunz, J. Zahn and Cheng Dong, 2006, "Design of a side-view particle imaging velocimetry flow system for cell-substrate adhesion studies", J. Biomech. Eng,, 128, pp. 271-278
  • Cheng Dong, S. Liang, M. Slattery and H.-H. Peng, 2006, "Inflammation and cancer: Role of intercellular and intracellular interactions mediated by mechanics and chemistry", The 5th World Congress of Biomechanics, 39, (1), pp. 20.6
  • S. Liang, C. Fu, D. Wagner, Cheng Dong and M. Long, 2006, "2D kinetics of B2 integrin and ICAM-1 bindings between leukocytes and melanoma cells", The 5th World Congress of Biomechanics, 39, (1), pp. 20.6
  • M. Hoskins, R. Kunz and Cheng Dong, 2006, "Development of a computational model of leukocyte-tumor cell adhesion to endothelium in shear flow", Annuals of Biomedical Engineering, pp. p. 30
  • S. Liang, A. Sharma, B. Chatterjee, G. Robertson and Cheng Dong, 2006, "Targeting mutant (V600E) B-Raf interrupts leukocyte-facilitated melanoma migration", Annuals of Biomedical Engineering, pp. p. 97
  • H. H. Peng, L. Hodgson, A. J. Henderson and Cheng Dong, 2005, "Involvement of phospholipase C signaling in melanoma cell-induced endothelial junction disassembly", Frontiers in Bioscience, 10, pp. 1597-1606
  • S. Liang, M. Slattery and Cheng Dong, 2005, "Shear stress and shear rate differentially affect the multi-step process of PMN-facilitated melanoma adhesion", Experimental Cell Research, 310, pp. 282-292
  • M. Slattery, S. Liang and Cheng Dong, 2005, "Distinct role of hydrodynamic shear in PMN-facilitated melanoma cell extravasation", Am J. Physiol,, 288, (4), pp. C831-839
  • Cheng Dong, C. Slattery, S. Liang and H.-H. Peng, 2005, "Melanoma cell extravasation under flow conditions is modulate by leukocytes and endogenously produced interleukin 8", Molecular and Cellular Mechanics, 2, (3), pp. 145-159
 

About

The Penn State Department of Engineering Science and Mechanics (ESM) is an internationally distinguished department that is recognized for its globally competitive excellence in engineering and scientific accomplishments, research, and educational leadership.

Our Engineering Science program is the official undergraduate honors program of the College of Engineering, attracting the University’s brightest engineering students. We also offer graduate degrees in ESM, engineering mechanics, engineering at the nano-scale, and an integrated undergraduate/graduate program.

Department of Engineering Science and Mechanics

212 Earth and Engineering Sciences Building

The Pennsylvania State University

University Park, PA 16802

Phone: 814-865-4523