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Patrick Drew

Associate Professor

Affiliation(s):

  • Engineering Science and Mechanics
  • Biomedical Engineering

W317 Millennium Science Complex

pjd17@psu.edu

814-863-1473

Personal or Departmental Website

Research Areas:

Brain Science and Neural Engineering

Interest Areas:

Neuroscience, neurovascular coupling.

 
 

 

Education

  • BS, Biology, California Institute of Technology, 1999
  • Ph D, Neuroscience, Brandeis University, 2004

Publications

Book, Chapters

  • A Shih, P Drew and D Kleinfeld, 2014, Imaging vasodynamics in the awake mouse brain with two-photon microscopy, Springer Science + Business Media, NY, pp. 55-73
  • J Driscoll, A Shih, Patrick Drew, I Valmianski, G Cauwenberg ands, D , 2011, Two-photon imaging of blood flow in rat cortex., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 927-938

Journal Articles

  • Y R Gao, Y Ma, Q Zhang, A T Winder, Z Liang, L Antinori, Patrick Drew and Nanyin Zhang, 2016, "Time to wake up: Studying neurovascular coupling and brain-wide circuit function in the un-anesthetized animal.", NeuroImage
  • Y R Gao and Patrick Drew, 2016, "Effects of Voluntary Locomotion and Calcitonin Gene-Related Peptide on the Dynamics of Single Dural Vessels in Awake Mice.", The Journal of neuroscience : the official journal of the Society for Neuroscience, 36, (8), pp. 2503-16
  • Y R Gao, S E Greene and Patrick Drew, 2015, "Mechanical restriction of intracortical vessel dilation by brain tissue sculpts the hemodynamic response.", NeuroImage, 115, pp. 162-76
  • M J Shirey, J B Smith, S E Greene, B X Huo and Patrick Drew, 2015, "Brief anesthesia, but not voluntary locomotion, significantly alters cortical temperature.", Journal of neurophysiology, 114, (1), pp. 309-22
  • B X Huo, S E Greene and Patrick Drew, 2015, "Venous cerebral blood volume increase during voluntary locomotion reflects cardiovascular changes.", NeuroImage, 118, pp. 301-312
  • A Y Shih, C Rühlmann, P Blinder, A Devor, Patrick Drew, B Friedman, P M Knutsen, P D Lyden, C Matéo, L Mellander, N Nishimura, C B Schaffer, P S Tsai and D Kleinfeld, 2015, "Robust and fragile aspects of cortical blood flow in relation to the underlying angioarchitecture.", Microcirculation (New York, N.Y. : 1994), 22, (3), pp. 204-18
  • Bing-Xing Huo, Yu-Rong Gao and Patrick Drew, 2015, "Quantitative separation of arterial and venous cerebral blood volume increases during voluntary locomotion.", 105, pp. 369-79
  • A Letourneur, V Chen, G Waterman and Patrick Drew, 2014, "A method for longitudinal, transcranial imaging of blood flow and remodeling of the cerebral vasculature in postnatal mice", Physiological Reports, 2, (12), pp. 10
  • yu-Rong Gao and Patrick Drew, 2014, "Determination of vessel cross-sectional area by thresholding in Radon space."
  • Bing-Xing Huo, Jared B Smith and Patrick Drew, 2014, "Neurovascular Coupling and Decoupling in the Cortex during Voluntary Locomotion.", Journal of Neuroscience, 34, (33), pp. 10975-81
  • Patrick Drew and Y Gao, 2014, "Automated measurement of vessel cross-sectional area in by thresholding in Radon space", Journal of Cerebral Blood Flow and Metabolism, 34, pp. 1180-1187
  • Jonathan D Driscoll, Andy Y Shih, Patrick Drew, Gert Cauwenberghs and David Kleinfeld, 2013, "Two-photon imaging of blood flow in the rat cortex.", 8, pp. 759-67
  • Andy Y Shih, Celine Mateo, Patrick Drew, Philbert S Tsai and David Kleinfeld, 2012, "A polished and reinforced thinned-skull window for long-term imaging of the mouse brain."
  • A Y Shih, J D Driscoll, P J Drew, N Nishimura, C B Schaffer and D Kleinfeld, 2012, "Two-photon microscopy as a tool to study blood flow and neurovascular coupling in the rodent brain", J Cereb Blood Flow Metab, 32, (7), pp. 277-309
  • David Kleinfeld, Pablo Blinder, Patrick Drew, Jonathan D Driscoll, Arnaud Muller, Philbert S Tsai and Andy Y Shih, 2011, "A guide to delineate the logic of neurovascular signaling in the brain.", 3, (1)
  • Patrick Drew, Andy Y Shih and David Kleinfeld, 2011, "Fluctuating and sensory-induced vasodynamics in rodent cortex extend arteriole capacity.", 108, (20), pp. 8473-8478
  • Patrick Drew, Andy Y Shih, Jonathan D Driscoll, Per Magne Knutsen, Pablo Blinder, Dimitrios Davalos, Katerina Akassoglou, Philbert S Tsai and David Kleinfeld, 2010, "Chronic optical access through a polished and reinforced thinned skull.", 7, (12), pp. 981-984
  • Patrick Drew, Pablo Blinder, Gert Cauwenberghs, Andy Y Shih and David Kleinfeld, 2010, "Rapid determination of particle velocity from space-time images using the Radon transform.", 29, (1-2), pp. 5-11
  • Andy Y Shih, Beth Friedman, Patrick Drew, Philbert S Tsai, Patrick D Lyden and David Kleinfeld, 2009, "Active dilation of penetrating arterioles restores red blood cell flux to penumbral neocortex after focal stroke.", 29, (4), pp. 738-51
  • Philbert S Tsai, John P Kaufhold, Pablo Blinder, Beth Friedman, Patrick Drew, Harvey J Karten, Patrick D Lyden and David Kleinfeld, 2009, "Correlations of neuronal and microvascular densities in murine cortex revealed by direct counting and colocalization of nuclei and vessels.", 29, (46), pp. 14553-70
  • Lu Li, Kevin J Bender, Patrick Drew, Shantanu P Jadhav, Emily Sylwestrak and Daniel E Feldman, 2009, "Endocannabinoid signaling is required for development and critical period plasticity of the whisker map in somatosensory cortex.", 64, (4)
  • Patrick Drew and Daniel E Feldman, 2009, "Intrinsic signal imaging of deprivation-induced contraction of whisker representations in rat somatosensory cortex.", 19, (2), pp. 331-48
  • Patrick Drew, Jeff H Duyn, Eugene Golanov and David Kleinfeld, 2008, "Finding coherence in spontaneous oscillations.", 11, (9)
  • Jason Wolfe, Dan N Hill, Sohrab Pahlavan, Patrick Drew, David Kleinfeld and Daniel E Feldman, 2008, "Texture coding in the rat whisker system: slip-stick versus differential resonance."
  • Patrick Drew and Daniel E Feldman, 2007, "Representation of moving wavefronts of whisker deflection in rat somatosensory cortex.", 98, (3), pp. 1566-80
  • P J Drew and L F Abbott, 2006, "Extending the effects of spike-timing-dependent plasticity to behavioral timescales", 103, (23), pp. 8876-81
  • P J Drew and L F Abbott, 2006, "Models and properties of power-law adaptation in neural systems", 96, (2), pp. 826-81
  • S Fusi, P J Drew and LF Abbott, 2005, "Cascade models of synaptically stored memories", 45, (2), pp. 2697-706
  • P J Drew and L F Abbott, 2003, "Model of song selectivity and sequence generation in area HVc of the songbird", 89, (5)
  • Patrick Drew, R Sayres, K Watanabe and S Shimojo, 2001, "Pupillary response to chromatic flicker", (136)

Research Projects

  • September 2015 - May 2019, "CRCNS:US-French Research Proposal: Neurovascular coupling-democracy or oligarchy?," (Sponsor: NIH).
  • September 2014 - June 2019, "Craniosynostosis Network (Project 1: From Skull Shape to Cell Activity in Coronal)," (Sponsor: NIH).
  • March 2013 - January 2018, "Imaging neurovascular coupling and functional connectivity in the awake behaving brain," (Sponsor: NIH).

Honors and Awards

Service

Service to Penn State:

  • , Hosted lab experience for high school students thorough the ScienceU program, July 2016
  • Moderator, Senior Thesis Proposal, January 2014 - January 2016
  • Elected RepresentativeGraduate Council, September 2014 - June 2016
  • , Director of Optical Imaging for the Social, Life and Engineering, January 2010 - 2015
  • Faculty Advisor, PSU Neuroscience Student Society, September 2013 - September 2015
  • , Invited panelist MRSEC “Women in STEM” mixer, March 2014
  • , CoE REU Proposals, Reviewer, 2014 - 2014
  • Committee Member, ESM Undergraduate Curriculum Committee, October 2012
  • Member, Joint MD-PHD in Engineering Science and Mechanics Committee, December 2010
  • Member, ESM Undergraduate Curriculum Committee, October 2012
  • Member, Neural Engineering candidacy exam committee, September 2010
  • Member, MD/PhD Program Committee, September 2010
  • , Joint appointment with the Department of Neurosurgery, Milton S. Hershey College of Medicine, June 2010
  • , Admissions committee, Molecular, Cellular and Integrative Biosciences, Admissions committee, Molecular, Cellular and Integrative Biosciences, November 2015
  • , June 2016
  • , Bioengineering Graduate program admissions committee, June 2015
  • Committee Member, Interdepartmental Graduate Program in Bioengineering Advisory Committee, January 2017
  • Member, Center for Neural Engineering, January 2010
  • Member, Huck Institute for Life Sciences, January 2010
  • Member, Materials Research Institute, January 2010
  • Member, Penn State Institute for Neuroscience, January 2010
  • Member, Neuroscience Graduate Curriculum Committee, July 2013
  • Member, MD/PhD Steering Committee, March 2013
  • Member, Center for Molecular Investigation of Neurological Disorders, May 2013
  • Advisor, Schreyer Honors College, September 2010
  • on-going research collaboration with Dr. Kevin Cockroft on imaging the effects of vasospasm on the cerebral microvasculatureDepartment of Neurosurgery, Milton S. Hershey College of Medicine, September 2011
  • Joint AppointmentDepartment of Neurosurgery, Milton S. Hershey College of Medicine, June 2010

Service to External Organizations:

  • Co-Organizer, program committee, Optics and the Brain, April 2016 - April 2016
  • Reviewer, Reviewer for Computational and Systems Neurosceince Conference, December 2016
  • Co-ModeratorBrain equations: challenges and next generation mathematical models, April 2015
  • , Workshop leader, Focus Program on Neurovascular Coupling And Related Phenomena, July 2014
 


 

About

The Penn State Department of Engineering Science and Mechanics (ESM) is an internationally distinguished department that is recognized for its globally competitive excellence in engineering and scientific accomplishments, research, and educational leadership.

Our Engineering Science program is the official undergraduate honors program of the College of Engineering, attracting the University’s brightest engineering students. We also offer graduate degrees in ESM, engineering mechanics, engineering at the nano-scale, and an integrated undergraduate/graduate program.

Department of Engineering Science and Mechanics

212 Earth and Engineering Sciences Building

The Pennsylvania State University

University Park, PA 16802

Phone: 814-865-4523